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Safety and Tolerability of Gene Therapy With an Adeno-Associated Virus (AAV) Borne GAD gene for Parkinsons Disease: An Open Label, Phase I Trial
Lancet 369:2097-2105,2056, Kaplitt,M.G.,et al, 2007
See this aricle in Pubmed

Article Abstract
AAV-GAD gene therapy of the subthalamic nucleus is safe and well tolerated by patients with advanced Parkinsons disease, suggesting that in-vivo gene therapy in the adult brain might be safe for various neurodegenerative diseases.
 
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advances in neurology
degenerative diseases of CNS
gene therapy
glutamic acid decarboxylase
Parkinson disease
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safety
subthalamic nucleus
treatment of neurologic disorder
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